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Noninvasive, label-free, threedimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissue
Jinping He
2016-07
Source Publicationwww.nature.com/Scientific Reports
Issue6Pages:1-11
Abstract
Skin cancer is one of the most common cancers. Melanoma accounts for less than 2% of skin cancer cases but causes a large majority of skin cancer deaths. Early detection of malignant melanoma remains the key factor in saving lives. However, the melanoma diagnosis is still clinically challenging.

Here, we developed a confocal photothermal microscope for noninvasive, label-free, three-dimensional imaging of melanoma. The axial resolution of confocal photothermal microscope is ~3 times higher than that of commonly used photothermal microscope. Three-dimensional microscopic distribution of melanin in pigmented lesions of mouse skin is obtained directly with this setup. Classic morphometric and fractal analysis of sixteen 3D images (eight for benign melanoma and eight for malignant) showed a capability of pathology of melanoma: melanin density and size become larger during the melanoma growth, and the melanin distribution also becomes more chaotic and unregulated. The results suggested new options for monitoring the melanoma growth and also for the melanoma diagnosis.
Subject Area天文技术与方法
Language英语
Document Type期刊论文
Identifierhttp://ir.niaot.ac.cn/handle/114a32/1357
Collection中国科学院南京天文光学技术研究所_期刊论文
中科院天文光学技术重点实验室_期刊论文
Affiliation南京天文光学技术研究所
Recommended Citation
GB/T 7714
Jinping He. Noninvasive, label-free, threedimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissue[J]. www.nature.com/Scientific Reports,2016(6):1-11.
APA Jinping He.(2016).Noninvasive, label-free, threedimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissue.www.nature.com/Scientific Reports(6),1-11.
MLA Jinping He."Noninvasive, label-free, threedimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissue".www.nature.com/Scientific Reports .6(2016):1-11.
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